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Brewery Setup Blog

Tangential flow filtration

May 05, 2017
helen

7998
beer filter

Tangential flow filtration

To clarify some beer before filling, we can use different kinds of filter, such as plate-frame filter, kieselguhr filter etc. It is normally used in beer brewing equipment field. Recently one customer in French mentioned tangential flow filtration and we searched some information on the internet, hope this also can help you further in beer brewing equipment.

Tangential flow filtration (TFF) is a rapid and efficient method for separation and purification of biomolecules. It can be applied to a wide range of biological fields such as immunology, protein chemistry, molecular biology, biochemistry, and microbiology. TFF can be used to concentrate and desalt sample solutions ranging in volume from 10 mL to thousands of liters. It can be used to fractionate large from small biomolecules, harvest cell suspensions, and clarify fermentation broths and cell lysates.

Why Use Tangential Flow Filtration?

Easy to set up and use – Simply connect the TFF device to a pump and pressure gauge(s) with tubing and a few fittings, add your sample to the reservoir, and begin filtration.

Fast and efficient – It is easier to set up and much faster than dialysis. Higher concentrations can be achieved in less time than when using centrifugal devices or stirred cells.

Perform two steps with one system – Concentrate and diafilter a sample on the same system, saving time and avoiding product loss.

Can be scaled up or scaled down – Materials of construction and cassette path length allow conditions established during pilot-scale trials to be applied to process scale applications. TFF devices that can process sample volumes as small as 10 mL or as large as thousands of liters are available.

Economical – TFF devices and cassettes can be cleaned and reused, or disposed of after single use. A simple integrity test can be performed to confirm that membrane and seals are intact.

Edited by Derrick
Sales Manager in Tiantai Company
Email:brewery@cnbrewery.com

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